?-Glucan: Mode of Action and Its Uses in Fish Immunomodulation
نویسندگان
چکیده
?-glucan is considered as an effective immunostimulant because of its binding capacity to different receptors on leukocytes leading the stimulation immune responses including bactericidal activity, cytokine productivity, and survival fit ability at cellular levels. In response cell surface receptors, stimulates release cytokines chemokines. It has been found that these signaling proteins eventually stimulate immunocompetent cells in fish such monocytes, macrophages, neutrophils for killing pathogens by phagocytosis, oxidative burst, cytotoxic activities. They also procreate immunological memories specific antibodies through activation T B lymphocytes. Researchers have proved can modulate some important biochemical (serum hemoglobin, serum protein, total hemocyte count) (lysozyme phagocytic burst phenoloxidase activity) properties providing more competent profile treating aquatic organisms. ?-glucan-supplemented showed limited sensitivity genes involved acute inflammatory reactions. Findings shown exerts a positive impact organisms’ immunity, enhancing their disease resistance increasing functional decreasing deleterious responses. This review focuses basic bump shellfish immunity recent information uses progressive aquaculture.
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ژورنال
عنوان ژورنال: Frontiers in Marine Science
سال: 2022
ISSN: ['2296-7745']
DOI: https://doi.org/10.3389/fmars.2022.905986